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ABC转运蛋白及其相关的多药抗性研究现状

引用本文：孙铭优,吴照晨,王斌,王婷婷,李雪明,宋佳露,刘鹏飞,刘西莉.ABC转运蛋白及其相关的多药抗性研究现状.植物保护学报,2022,49(1):374-382

DOI：10.13802/j.cnki.zwbhxb.2022.2021100

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作者	单位	E-mail
孙铭优	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193 沈阳中化农药化工研发有限公司, 新农药创制与开发国家重点实验室, 沈阳 110021
吴照晨	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193
王斌	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193 沈阳中化农药化工研发有限公司, 新农药创制与开发国家重点实验室, 沈阳 110021
王婷婷	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193
李雪明	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193
宋佳露	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193
刘鹏飞	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193	pengfeiliu@cau.edu.cn
刘西莉	中国农业大学植物保护学院, 农业农村部作物有害生物监测与绿色防控重点实验室, 北京 100193

中文摘要:ABC（ATP-binding cassette）转运蛋白是一类家族庞大、功能多样的跨膜转运蛋白，其广泛存在于原核和真核生物的各类细胞器中，负责多种物质的跨膜转运，从而调节生物体的一系列生命活动。近年来，越来越多ABC转运蛋白的种类及功能被报道，但是ABC蛋白家族的潜在成员以及功能仍然值得进一步探究和挖掘。该文对不同物种中ABC转运蛋白数量、结构域、功能、研究方法以及其参与调控病原菌多药抗性的研究现状进行综述，并对植物病原菌多药抗性的治理等进行展望。

中文关键词:ABC转运蛋白蛋白结构基因功能多药抗性

Research status of ATP-binding cassette transporters and related multidrug resistance

Author Name	Affiliation	E-mail
Sun Mingyou	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals Research and Development Company Limited, Shenyang 110021, Liaoning Province, China
Wu Zhaochen	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China
Wang Bin	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals Research and Development Company Limited, Shenyang 110021, Liaoning Province, China
Wang Tingting	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China
Li Xueming	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China
Song Jialu	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China
Liu Pengfei	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China	pengfeiliu@cau.edu.cn
Liu Xili	Key Laboratory of Pest Monitoring and Green Management, Ministry of Agriculture and Rural Affairs College of Plant Protection, China Agricultural University, Beijing 100193, China

Abstract:ATP-binding cassette(ABC) transporters are a large family of transmembrane proteins with diverse functions, they are widely present in various organelles of prokaryotic and eukaryotic organisms and are responsible for the transmembrane transport of various substances, thereby regulating a series of life activities. In recent years, more and more types and functions of ABC transporters have been reported, however, the potential members and functions of the ABC protein family are still worthy of further exploration. The number, domains, functions, and research methods of ABC transporters in different species are reviewed, as well as their participation in regulating the multidrug resistance of plant pathogens are discussed. Besides, the management strategies for multidrug resistance of plant pathogens are also prospected.

keywords:ABC transporter protein structure gene function multidrug resistance

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